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Title: The "J curve" problem revisited: old and new findings
Authors: Grassi, Guido 
Quarti-Trevano, Fosca 
Dell'Oro, Raffaella 
Mancia, Giuseppe 
Keywords: ; ; ; ; ; ; ; ; ;
Issue Date: Aug-2010
Journal: Current hypertension reports 
Abstract: This paper critically addresses the issue of the "J-curve" paradox--the finding described in studies performed about 30 years ago indicating that treatment-induced systolic blood pressure values below 120 or 125 mm Hg and diastolic blood pressure values below 75 mm Hg are characterized by an increase, rather than a reduction, in the incidence of coronary events. This paper focuses on four major subjects: 1) the benefits of a lower blood pressure target during treatment; 2) the historical background of the "J-curve" phenomenon; 3) the evidence collected in recent clinical trials regarding the existence of a "J-curve" in treated hypertensive patients; and 4) the recent recommendations by the Task Force Committee of the European Society of Hypertension on blood pressure goals to be achieved during treatment.
ISSN: 1522-6417
Appears in Collections:Publikime ne Revista te Huaja

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